Identification of unfavourable paired cell interactions in follicular lymphoma using hypothesized interaction distribution (HID) analysis
نویسندگان
چکیده
Objective Histopathological prognostication relies on pattern recognition, but as the number of biomarkers increases, human prognostic pattern recognition ability decreases. We have developed an automated quantitative method, hypothesized interaction distribution (HID) analysis, for identifying prognostic patterns of multiple biomarkers in situ. For follicular lymphoma (FL) we have previously demonstrated favourable significance of the transcription factor Yin Yang 1 (YY1) and infiltrating T cells (CD3 +ve) and unfavourable significance of infiltrating macrophages (CD68 +ve).
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